Short Communication Geniposide decreases the level of Ab1242 in the hippocampus of streptozotocin-induced diabetic rats
نویسندگان
چکیده
Jianhui Liu1,2, Yonglan Zhang1,2,3, Xiaohong Deng1,2, and Fei Yin1,2* Chongqing Key Lab of Catalysis & Functional Organic Molecules, Chongqing Technology and Business University, Chongqing 400067, China Chongqing University Key Lab of Natural Medicines Research, Chongqing Technology and Business University, Chongqing 400067, China College of Chemistry and Chemical Engineering, Chongqing University, Chongqing 400030, China *Correspondence address. Tel/Fax: þ86-23-6276-9652; E-mail: [email protected]
منابع مشابه
Effect of Trigonelline on Dendritic Morphology in the Hippocampus and Prefrontal Cortex in Streptozotocin-Induced Diabetic Rats
Introduction: Diabetes mellitus causes adverse changes in the neurological morphology of the hippocampus and prefrontal cortex of the brain by increasing oxidative stress. Trigonelline has antihyperglycemic effects and can inhibit oxidative stress. The aim of this study was to evaluate the protective effect of trigonelline on dendritic changes in hippocampal and prefrontal cortex neurons in dia...
متن کاملThe Effect of 8 Weeks of Concurrent Training on BDNF Values of Brain Hippocampus, Cognitive Function, Blood Glucose and Insulin in Streptozotocin-Induced Diabetic Rats
Background: BDNF protein is the important neurotrophin that is involved in cognitive function. Diabetes can lead to impaired function and is a neurocognitive disorder's factor in hippocampus. Therefore, the purpose of this study was to evaluate the effect of 8 weeks of concurrent training on BDNF levels in the brain hippocampus and cognitive function of streptozotocin-induced diabetic rats. Me...
متن کاملNeuroprotective role of curcumin on the hippocampus against the structural and serological alterations of streptozotocin-induced diabetes in sprague dawely rats
Objective(s): Diabetes mellitus causes impaired memory and cognitive functions. The hippocampus plays a key role in memory and learning. Curcumin attenuates diabetic nephropathy in vivo. Curcumin has shown a neurogenic effect and cognition-enhancing potential in aged rats. The aim of this study is to evaluate the possible protective role of curcumin on the histological and serologicalchanges of...
متن کاملThe Effect of Cholesterol and Simvastatin on Passive Avoidance Memory of Streptozotocin-Induced Diabetic Rats
Introduction:Cholesterol has different effects on memory, and diabetes caused adverse effect on cognition. Since there is not enough evidence regarding the effect of cholesterol on memory of diabetic animals, the effects of cholesterol and simvastatin on the passive avoidance memory of diabetic rat were studied. Methods:The study was done on 60 male Wistar rats (180 ± 20g). Diabetes was in...
متن کاملEffects of amitriptyline and fluoxetine on synaptic plasticity and TNF-α level at hippocampus of streptozotocin-induced diabetic rats
Introduction: Studies have indicated that diabetes mellitus impairs hippocampus. Diabetes increases the risk of depression and treatment with antidepressants may affect learning and memory. The aim of this study was to evaluate the effects of amitriptyline and fluoxetine on synaptic plasticity and TNF-α level in the hippocampus of streptozotocin-induced diabetic rats. Methods: Experimenta...
متن کامل